{"id":172,"date":"2017-11-10T14:36:05","date_gmt":"2017-11-10T16:36:05","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=172"},"modified":"2017-11-22T11:45:37","modified_gmt":"2017-11-22T13:45:37","slug":"ian-castro-gamboa","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/governanca\/ian-castro-gamboa\/","title":{"rendered":"Ian Castro-Gamboa"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Professor Assistente Doutor
\nCoordenador de Bolsas INCTBioNat<\/h2>\n

Laborat\u00f3rio: <\/strong>N\u00facleo de Bioensaios, Bioss\u00edntese e Ecofisiologia de Produtos Naturais – NuBBE<\/p>\n

Telefone:<\/strong>\u00a0+55 16\u00a03301-9664<\/p>\n

E-mail:\u00a0<\/strong>ian.castro@gmail.com<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/9032973705204320<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n

Qu\u00edmica de produtos naturais, metabol\u00f4mica, desprelica\u00e7\u00e3o, EM, RMN, microorganismos, Bio-transforma\u00e7\u00e3o.<\/p>\n

Descri\u00e7\u00e3o<\/h2>\n

O nosso grupo de pesquisa trabalha na vertente da metabol\u00f4mica e t\u00e9cnicas de desreplica\u00e7\u00e3o fazendo uso de EM e RMN e modelos computacionais visando a elucida\u00e7\u00e3o in situ<\/em> de metab\u00f3litos secund\u00e1rios em extratos de alta complexidade molecular. Atualmente estudamos uma cole\u00e7\u00e3o de microorganismos isolados da rizosfera de Senna<\/em> spectabilis<\/em>, detectando metab\u00f3litos de interesse assim como fazendo uso desses microorganismos para a bio-tranforma\u00e7\u00e3o de f\u00e1rmacos, em especial antibi\u00f3ticos em desuso, com o objetivo de regenerar e\/ou aumentar as suas propriedades farmacol\u00f3gicas iniciais.<\/p>\n

Principais Trabalhos Desenvolvidos<\/h2>\n
    \n
  1. Selegato, D.M., Monteiro, A.F., Vieira, N.C., Cardoso, P., Pavani, V.D., Bolzani, V.S., Castro-Gamboa, I. UPDATE: biological and chemical aspects of Senna spectabilis <\/em>(Fabaceae). Journal of the Brazilian Chemical Society. DOI: 10.21577\/0103-5053.20160322, 2017.<\/li>\n
  2. Carnevale Neto, F., Pilon, A.C., Selegato, D.M., Freire, R.T., Gu, H., Raftery, D., Lopes, N.P. Dereplication of natural producs using GC-TOF Mass Spectrometry: Improved metabolite indentification by spectral deconvolution ratio analysis. Metabolomics. DOI: 10.3389\/fmolb.2016.00059, 2016.<\/li>\n
  3. Selegato, D.M., Freire, R.T., Tannu?s, A., Castro-Gamboa, I. New Dereplication Method Applied to NMR-Based Metabolomics on Different Fusarium<\/em> Species Isolated from Rhizosphere of Senna<\/em> spectabilis<\/em>.\u00a0 Journal of the Brazilian Chemical Society. DOI 10.5935\/0103-5053.20160139, 2016.<\/li>\n
  4. Pilon, A.C., Carnevale Neto, F., Freire, R.T., Cardoso, P., Carneiro, R.L., Bolzani, V. S., Castro-Gamboa I. Partial least squares model and design of experiments toward the analysis of the metabolome of Jatropha<\/em> gossypifolia<\/em> leaves: Extraction and chromatographic fingerprint optimization. Journal of Separation Sciences. DOI 10.1002\/jssc.201500892. 2016.<\/li>\n
  5. Carnevale Neto, F., Pilon, A.C., Gu, H., Freire, R.T., Cardoso P., Raftery, D., Da S Bolzani, V., Castro-Gamboa I. Dereplication of natural products based on ratio analysis H-1 NMR spectroscopy and HPLC-DAD-ESI-QToF-MS\/MS. Planta Medica, V. 81, p. 950, 2015.<\/li>\n
  6. Pilon, A.C., Carneiro, R., Carnevale, F., Bolzani, da S. V., Castro-Gamboa, I. Interval Multivariate Curve Resolution in the dereplication of HPLC-DAD data from Jatropha<\/em> gossypifolia<\/em>. Phytochemical Analysis. DOI: DOI: 10.1002\/pca.2423. 2013.<\/li>\n
  7. Carnevale, F., Siquitelli, C., Pilon, A.C., Silva, D.H.S., Bolzani, da S. V., Castro-Gamboa I. Dereplication of phenolic derivatives of Qualea<\/em> grandiflora<\/em> and\u00a0 Qualea<\/em> cordata<\/em> (Vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS\/MS. Journal of the Brazilian Chemistry Society. http:\/\/dx.doi.org\/10.5935\/0103-5053.20130098. 2013.<\/li>\n
  8. Castro-Gamboa I., Carnevale Neto, F., Freire, R., Pilon, A.C., Cardoso, P., Bolzani, da S.V. How to separate the wheat from the chaff? Exploring Brazilian biodiversity using NMR dereplication techniques. Pharmaceutical Biology, v. 50, p. 566-567, 2012.<\/li>\n<\/ol>\n

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