{"id":178,"date":"2017-11-10T14:44:29","date_gmt":"2017-11-10T16:44:29","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=178"},"modified":"2017-11-22T11:45:31","modified_gmt":"2017-11-22T13:45:31","slug":"adriano-d-andricopulo","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/governanca\/adriano-d-andricopulo\/","title":{"rendered":"Adriano D. Andricopulo"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Coordenador Cient\u00edfico INCTBioNat<\/h2>\n

Laborat\u00f3rio: <\/strong>Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC)<\/p>\n

Website:<\/strong>\u00a0http:\/\/www.lqmc.ifsc.usp.br<\/a><\/p>\n

E-mail:\u00a0<\/strong>aandrico@ifsc.usp.br<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/5598322661148873<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n
    \n
  • Qu\u00edmica Medicinal e Planejamento de F\u00e1rmacos<\/li>\n
  • Doen\u00e7as Tropicais Negligenciadas<\/li>\n
  • Novos Agentes Antic\u00e2ncer<\/li>\n
  • Biodiversidade e Desenvolvimento de Bases de Dados<\/li>\n<\/ul>\n

    Principais Trabalhos Desenvolvidos<\/h2>\n
      \n
    1. Ferreira, L.G.; Andricopulo, A.D. Targeting Cysteine Proteases in Trypanosomatid Disease Drug Discovery. Pharmacology & Therapeutics<\/em>, 180<\/em>, 49-61,<\/li>\n
    2. Pilon, A.C.; Valli, M.; Dameto, A.C.; Pinto, M.E.F.E.; Freire, R.T.; Andricopulo, A.D.; Bolzani, V.S. NuBBEDB: an Updated Database to Uncover Chemical and Biological Information from Brazilian Biodiversity. Scientific Reports<\/em>, 7<\/em>, 7215, 2017<\/strong>.<\/li>\n
    3. Ferreira, L.G.; Andricopulo, A.D. Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design. Frontiers in Pharmacology<\/em>, 8, in press<\/em>, 2017<\/strong>.<\/li>\n
    4. Mafud, A.C.; Ferreira, L.G.; Mascarenhas, Y.P.; Andricopulo, A.D.; Moraes, J. Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches. Trends in Parasitology<\/em>, 11<\/em>, 874-886,<\/li>\n
    5. Ferreira, L.G.; Andricopulo, A.D. Drug Repositioning Approaches to Parasitic Diseases: A Medicinal Chemistry Perspective. Drug Discovery Today<\/em>, 21<\/em>, 1699-1710, 2016<\/strong>.<\/li>\n
    6. Santos, M.S.; Fernandes, D.C.; Rodrigues, M.T.; Regiani, T.; Andricopulo, A.D.; Ruiz, A.L.T.G.; Vendramini-Costa, D.B.; Carvalho, J.E.; Eberlin, M.N.; Coelho, F. Diastereoselective Synthesis of Biologically Active Cyclopenta[b]indoles. Journal of Organic Chemistry<\/em>, 81<\/em>, 6626-6639,<\/li>\n
    7. Magalhaes, L.G.; Marques, F.B.; Fonseca, M.B.; Rogerio, K.R.; Graebin, C.S.;\u00a0Andricopulo, A.D.<\/strong> Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity. Plos One<\/em>, 11<\/em>, e0160842,<\/li>\n
    8. Sueth-Santiago, V.; Moraes, J.B.B.; Alves, E.S.S.; Vannier-Santos, M. A.; Freire-de-Lima, C.G.; Rocha, J.D.B.; Castro, R.N.; Mendes-Silva, G.P.; Cistia, C.N.; Magalhaes, L.G.; Santanna, C.M.R.;Andricopulo, A.D.<\/strong>; Decote-Ricardo, D.; Lima, M.E.F. The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi<\/em>: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies. Plos One<\/em>, 11<\/em>, e0162926, 2016<\/strong>.<\/li>\n
    9. Santos, R.N.; Morcos, F.; Jana, B.; Andricopulo, A.D.; Onuchic, J.N. Dimeric interactions and complex formation using direct coevolutionary couplings. Scientific Reports<\/em>, 5<\/em>, 13652, 2015<\/strong>.<\/li>\n
    10. Ferreira, R.S.; Dessoy, M.A.; Pauli, I.; Souza, M.L.; Krogh, R.; Sales, A.I.L.; Oliva, G.; Dias, L.C.; Andricopulo, A.D. Synthesis, Biological Evaluation, and Structure-Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi<\/em> Journal of Medicinal Chemistry<\/em>, 57<\/em>, 2380-2392, 2014<\/strong>.<\/li>\n<\/ol>\n

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