{"id":201,"date":"2017-11-16T12:07:57","date_gmt":"2017-11-16T14:07:57","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=201"},"modified":"2017-11-22T11:51:38","modified_gmt":"2017-11-22T13:51:38","slug":"diego-veras-wilke","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/pesquisadores\/diego-veras-wilke\/","title":{"rendered":"Diego Veras Wilke"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"<\/strong>Doutor
\nProfessor Adjunto III<\/h2>\n

Laborat\u00f3rio: <\/strong>Bioprospec\u00e7\u00e3o e Biotecnologia Marinha (LaBBMar)<\/p>\n

Telefone:<\/strong>\u00a0+55 85\u00a03366 8073 \/ Celular: +55 85\u00a098875 3535<\/p>\n

E-mail:\u00a0<\/strong>diegowilke@gmail.com<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/5313374711687727<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n

Biprospec\u00e7\u00e3o de produtos naturais marinhos com atividade antitumoral.<\/p>\n

Descri\u00e7\u00e3o<\/h2>\n

Prof. Diego Wilke. Possui gradua\u00e7\u00e3o em Biologia (2005) e doutorado em Farmacologia pela Universidade Federal do Cear\u00e1 (2009) trabalhando com produtos naturais marinhos. Fez p\u00f3s-doutorado no Centro de Pesquisas Gon\u00e7alo Moniz-FIOCRUZ (2011) trabalhando com imunidade inata. Atualmente \u00e9 professor adjunto III da Universidade Federal do Cear\u00e1. \u00c9 coordenador do Laborat\u00f3rio de Bioprospec\u00e7\u00e3o e Biotecnologia Marinha (LaBBMar) onde desenvolve pesquisa na \u00e1rea de farmacologia e biotecnologia. Desenvolve projetos de prospec\u00e7\u00e3o e determina\u00e7\u00e3o de mecanismos de a\u00e7\u00e3o de produtos naturais marinhos com atividade citot\u00f3xica ou imunomoduladora. \u00c9 tutor do PET Medicina da UFC.<\/p>\n

Principais Trabalhos Desenvolvidos<\/h2>\n

O Laborat\u00f3rio de Bioprospec\u00e7\u00e3o e Biotecnologia Marinha,\u00a0coordenado pelo Prof. Dr. Diego Wilke, vem desenvolvendo projetos\u00a0de prospec\u00e7\u00e3o de produtos naturais marinhos com atividade biol\u00f3gica. Diversos projetos s\u00e3o realizados interagindo com\u00a0grupos de pesquisa nacionais\u00a0e internacionais. Nesse contexto,\u00a0realizamos\u00a0estudos com inverterbrados, algas e microrganismos marinhos como fonte de mol\u00e9culas com potencial farmacol\u00f3gico relevante para a sa\u00fade humana. Temos encontrado e demonstrado o potencial antitumoral de mol\u00e9culas citot\u00f3xicas e elucidado os seus mecanismos de a\u00e7\u00e3o. Outra abordagem vem sendo realizada com mol\u00e9culas n\u00e3o t\u00f3xicas, que inibem o crescimento do tumor por imunomodula\u00e7\u00e3o ou modifica\u00e7\u00e3o do microambiente tumoral. Adicionalmente, tamb\u00e9m temos\u00a0investigado\u00a0aspectos\u00a0relacionados\u00a0\u00e0 produ\u00e7\u00e3o de produtos naturais marinhos atrav\u00e9s de minera\u00e7\u00e3o gen\u00f4mica, metagen\u00f4mica e metabol\u00f4mica. Para mais informa\u00e7\u00f5es acesse: labbmar.ufc.br<\/p>\n

 <\/p>\n

Algumas publica\u00e7\u00f5es selecionadas:<\/strong><\/p>\n

    \n
  1. AMBROSE, ANDREW J. ; SANTOS, EVELYNE A. ; JIMENEZ, PAULA C. ; ROCHA, D. D. ;\u00a0WILKE, D. V.<\/strong>; BEUZER, PAOLO ; AXELROD, JOSH ; KANDULURU, ANANDA KUMAR ; FUCHS, PHILIP L. ; CANG, HU ;\u00a0Costa-Lotufo, Let\u00edcia V.\u00a0; CHAPMAN, ELI ; LA CLAIR, JAMES J. Ritterostatin GN1N, a Cephalostatin-Ritterazine bis-Steroidal Pyrazine Hybrid, Selectively Targets GRP78. ChemBioChem, v18:6, p. 505-510, 2017.<\/li>\n
  2. PINTO, FRANCISCO ; ALMEIDA, JOS\u00c9 GUSTAVO ; SILVEIRA, EDILBERTO ; COSTA, ARINICE ;\u00a0GUIMAR\u00c3ES, LARISSA\u00a0;\u00a0WILKE, DIEGO<\/strong>\u00a0; COSTA-LOTUFO, LET\u00cdCIA ; TORRES, MARIA DA CONCEI\u00c7\u00c3O ; PESSOA, OT\u00cdLIA DEUSD\u00caNIA . Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis. Journal of the Brazilian Chemical Society, \u00a0v. 28, p. 485-491, 2016.<\/li>\n
  3. SILVA, AMARO ; GUIMAR\u00c3ES, LARISSA ; FERREIRA, ELTHON ; TORRES, MARIA DA CONCEI\u00c7\u00c3O ; DA SILVA, ALISON ; BRANCO, PAOLA ; OLIVEIRA, FRANCISCA ANDR\u00c9A ; SILVA, GENIVALDO ; WILKE, DIEGO<\/strong> ; SILVEIRA, EDILBERTO ; PESSOA, OT\u00cdLIA DEUSDENIA ; JIMENEZ, PAULA ; COSTA-LOTUFO, LETICIA . Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Actinomadura sp. Collected at the Saint Peter and Saint Paul Archipelago (Brazil). Journal of the Brazilian Chemical Society, v. 28, p. 465-474, 2016.<\/li>\n
  4. SANTOS, EVELYNE A. ; QUINTELA, AMANDA L. ; Ferreira, Elthon G. ; SOUSA, THICIANA S. ; PINTO, FRANCISCO DAS CHAGAS L. ;\u00a0HAJDU, Eduardo\u00a0; CARVALHO, MARIANA S. ; SALANI, SULA ;\u00a0ROCHA, DANILO D.\u00a0;\u00a0WILKE, D. V.<\/strong>\u00a0; TORRES, MARIA DA CONCEI\u00c7\u00c3O M. ; Jimenez, Paula C. ; Silveira, Edilberto R. ; LA CLAIR, JAMES J. ; Pessoa, Ot\u00edlia Deusd\u00eania L. ;\u00a0COSTA-LOTUFO, L. V.\u00a0. Cytotoxic Plakortides from the Brazilian Marine Sponge\u00a0\u00a0Plakortis <\/em>angulospiculatus<\/em>. Journal of Natural Products, v. 78, p. 996-1004, 2015.<\/li>\n
  5. ABREU, PAULA A. ; SOUSA, THICIANA S. ; JIMENEZ, PAULA C. ;\u00a0Wilke, Diego V.<\/strong>\u00a0;\u00a0ROCHA, DANILO D.\u00a0; FREITAS, HOZANA P. S. ; PESSOA, OT\u00cdLIA D. L. ; LA CLAIR, JAMES J. ;\u00a0Costa-Lotufo, Let\u00edcia V.\u00a0. Identification of Pyrroloformamide as a Cytokinesis Modulator. ChemBioChem, v15, p.501-506, 2014.<\/li>\n
  6. GUIMAR\u00c3ES, LARISSA\u00a0; JIMENEZ, PAULA ; SOUSA, THICIANA ; FREITAS, HOZANA ; ROCHA, DANILO ;\u00a0WILKE, D. V.<\/strong>\u00a0; MART\u00cdN, JES\u00daS ; REYES, FERNANDO ; DEUSD\u00caNIA LOIOLA PESSOA, OT\u00cdLIA ;\u00a0COSTA-LOTUFO, L. V.\u00a0. Chromomycin A2 Induces Autophagy in Melanoma Cells. Marine Drugs, v. 12, p. 5839-5855, 2014.<\/li>\n
  7. Wilke, Diego Veras<\/strong>;\u00a0JIMENEZ, Paula Christine\u00a0; Ara\u00fajo, Renata Mendon\u00e7a ; da Silva, Wildson Max Barbosa ; Pessoa, Ot\u00edlia Deusd\u00eania Loiola ; Silveira, Edilberto Rocha ;\u00a0PESSOA, Claudia\u00a0;\u00a0de Moraes, Manoel Odorico\u00a0; Skwarczynski, Mariusz ; Simerska, Pavla ; Toth, I. ;\u00a0Costa-Lotufo, Let\u00edcia Veras\u00a0. Pro-apoptotic activity of lipidic alpha-amino acids isolated from Protopalythoa variabilis. Bioorganic & Medicinal Chemistry, v. 18, p. 7997-8004, 2010.<\/li>\n
  8. WILKE, D. V.<\/strong>;\u00a0JIMENEZ, Paula Christine\u00a0;\u00a0PESSOA, Claudia\u00a0;\u00a0MORAES, Manoel Odorico de\u00a0;\u00a0ARAUJO, R. M.\u00a0;\u00a0SILVA, W. M. B.\u00a0;\u00a0SILVEIRA, Edilberto R\u00a0;\u00a0PESSOA, O D L\u00a0; BRAZFILHO, Raimundo ;\u00a0LOPES, Norberto Peporine\u00a0;\u00a0Costa-LOTUFO, L. V.\u00a0. Cytotoxic lipidic alpha-amino acids from the zoanthid Protopalythoa variabilis from the northeastern coast of Brazil. Journal of the Brazilian Chemical Society, v. 20, p. 1455-1459, 2009.<\/li>\n<\/ol>\n

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