{"id":244,"date":"2017-11-16T19:12:33","date_gmt":"2017-11-16T21:12:33","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=244"},"modified":"2017-11-22T11:53:32","modified_gmt":"2017-11-22T13:53:32","slug":"paula-christine-jimenez","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/pesquisadores\/paula-christine-jimenez\/","title":{"rendered":"Paula Christine Jimenez"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Doutora
\nProfessora Adjunto<\/h2>\n

Laborat\u00f3rio: <\/strong>Laborat\u00f3rio de Bioprospec\u00e7\u00e3o de Organismos Marinhos (BioproSP)<\/p>\n

Telefone:<\/strong>\u00a0+55 13\u00a03878 3965<\/p>\n

E-mail:\u00a0<\/strong>paulacjimenez@gmail.com<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/4248251483705135<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n

Bioprospec\u00e7\u00e3o Farmacol\u00f3gica de Produtos Naturais Marinhos.<\/p>\n

Descri\u00e7\u00e3o<\/h2>\n

O ambiente marinho ganhou import\u00e2ncia no contexto da bioprospec\u00e7\u00e3o de produtos naturais com potencial farmacol\u00f3gico apenas durante as \u00faltimas d\u00e9cadas. Ainda assim, atualmente, contam-se 8 medicamentos desenvolvidos a partir de princ\u00edpios ativos obtidos de fontes marinhas, e metade destes comp\u00f5em o arsenal de f\u00e1rmacos antic\u00e2ncer. A referida linha de pesquisa ocupa-se em buscar mol\u00e9culas com atividade antic\u00e2ncer em microrganismos e invertebrados marinhos, sobremaneira naqueles que ocorrem na costa brasileira, ainda pouco estudada nessa perspectiva. Para tanto, utilizamos duas abordagens prospectivas, uma fenot\u00edpica e outra alvo-direcionada. \u00c9 tamb\u00e9m objetivo desta linha o estudo do mecanismo de a\u00e7\u00e3o antic\u00e2ncer das mol\u00e9culas isoladas, utilizando modelos de cultura de c\u00e9lulas tumorais.<\/p>\n

Principais Trabalhos Desenvolvidos<\/h2>\n
    \n
  1. Trzoss, L.; Fukuda,T; Costa-Lotufo, L.V.; Jimenez, Paula<\/strong>; La Clair, J.J.; Fenical, W. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer protective protein dermcidin. Proccedings of the National Academy of Science USA, 111: 14687-14692, 2014.<\/li>\n
  2. Santos, E.A.; Quintela, A.L.; Ferreira, E.G.; Sousa, T.S.; Pinto, F.C.L.; Hajdu, E.; Carvalho, M.S.; Salani, Sula; Rocha, D.D.; Wilke, D.V.; Torres, M.C.M.; Jimenez, Paula C.<\/strong>; Silveira, E.R.; La Clair, James J.; Pessoa, O.D.L.; Costa-Lotufo, L.V. Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus. J Natl Prod, 78: 996-1004, 2015.<\/li>\n
  3. Sousa, T.S.; Jimenez, Paula C.<\/strong>; Ferreira, E.G.; Silveira, E.R.; Braz-Filho, R.; Pessoa, O.D.L.; Costa-Lotufo, L.V. Anthracyclinones from Micromonospora sp. J Natl Prod, 75: 489-493, 2012.<\/li>\n
  4. Guimar\u00e3es, Larissa ; Jimenez, Paula<\/strong> ; Sousa, Thiciana ; Freitas, Hozana ; Rocha, Danilo ; Wilke, Diego ; Mart\u00edn, Jes\u00fas ; Reyes, Fernando ; Deusd\u00eania Loiola Pessoa, Ot\u00edlia ; Costa-Lotufo, Let\u00edcia. Chromomycin A2 Induces Autophagy in Melanoma Cells. Mar Drugs, 12: 5839-5855, 2014.<\/li>\n
  5. Jimenez, Paula C.<\/strong>; Wilke, D.V.; Ferreira, E.G.; Takeara, R.; Moraes, M.O.; Silveira, E.R.; Lotufo, T.M.C.; Lopes, N.P.; Costa-Lotufo, L.V. Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei<\/em>. Mar Drugs, 10: 1092-1102, 2012.<\/li>\n
  6. Ambrose, A. J. ; Santos, E. A. ; Jimenez, Paula C.<\/strong> ; Rocha, D. D. ; Wilke, D. V. ; Beuzer, P. ; Axelrod, J. ; Kanduluru, A. K. ; Fuchs, P. L. ; Cang, H. ; Costa-Lotufo, L. V. ; Chapman, E. ; La Clair, J. J. . Ritterostatin Gn1n, a Cephalostatin-Ritterazine Bis-Steroidal Pyrazine Hybrid, Selectively Targets Grp78. ChemBiochem 506-510, 2017.<\/li>\n
  7. Abreu, Paula A.; Sousa, Thiciana S.; Jimenez, Paula C.<\/strong>; Wilke, Diego V.; Rocha, Danilo D.; Freitas, Hozana P. S.; Pessoa, Ot\u00edlia D.L.; La Clair, James J.; Costa-Lotufo, Let\u00edcia V. Identification of Pyrroloformamide as a Cytokinesis Modulator. ChemBioChem 15: 501-506, 2014.<\/li>\n
  8. Arthaud, Isabelle D. B. ; Rodrigues, Felipe A. R. ; Jimenez, Paula C.<\/strong> ; Montenegro, Raquel C. ; Angelim, Alysson L. ; Maciel, V\u00e2nia M. M. ; Silveira, Edilberto R. ; Freitas, Hozana P. S. ; Sousa, Thiciana S. ; Pessoa, Ot\u00edlia D. L. ; Lotufo, Tito M. C. ; Costa-Lotufo, Let\u00edcia V. Studies on the Secondary Metabolites of a Pseudoalteromonas sp. Isolated from Sediments Collected at the Northeastern Coast of Brazil. Chem Biodivers, 9: 418-427, 2012.<\/li>\n
  9. Ferreira, Elthon G.; M. Concei\u00e7\u00e3o M. Torres; Silva, A.B. ; Colares, L.L.F.; Pires, K.; Lotufo, Tito M.C.; Silveira, Edilberto R; Pessoa, Ot\u00edlia D.L.; Costa-Lotufo, Leticia V.; Jimenez, Paula C<\/strong>. Prospecting Anticancer Compounds in Actinomycetes Recovered from the Sediments of Saint Peter and Saint Paul’s Archipelago, Brazil. Chem Biodivers, 13: 1149-1157, 2016.<\/li>\n
  10. Silva, Amaro; Guimar\u00e3es, Larissa; Ferreira, Elthon; Torres, M. Concei\u00e7\u00e3o M.; Silva, Alison; Branco, Paola; Oliveira, F. Andr\u00e9a; Silva, Genivaldo; Wilke, Diego ; Silveira, Edilberto; Pessoa, Ot\u00edlia D.L.; Jimenez, Paula C.<\/strong> ; Costa-Lotufo, Leticia. Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Actinomadura sp. Collected at the Saint Peter and Saint Paul Archipelago (Brazil). J Braz Chem Soc 465-474, 2016.<\/li>\n<\/ol>\n

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