{"id":270,"date":"2017-11-16T19:40:10","date_gmt":"2017-11-16T21:40:10","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=270"},"modified":"2017-11-22T11:54:06","modified_gmt":"2017-11-22T13:54:06","slug":"valdecir-farias-ximenes","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/pesquisadores\/valdecir-farias-ximenes\/","title":{"rendered":"Valdecir Farias Ximenes"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Professor Associado<\/h2>\n

Laborat\u00f3rio: <\/strong>Bioqu\u00edmica de Processos Oxidativos<\/p>\n

Telefone:<\/strong>\u00a0+55 14\u00a03103-6088<\/p>\n

E-mail:\u00a0<\/strong>vfximenes@fc.unesp.br<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/4066413997908572<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n

Desenvolvimento e Aplica\u00e7\u00e3o de Sondas Fluorescentes e Baseadas em Dicro\u00edsmo Circular para Estudos de Intera\u00e7\u00e3o de Ligantes com Prote\u00ednas, Caracteriza\u00e7\u00e3o de Prote\u00ednas Amiloides, Determina\u00e7\u00e3o de Atividade Enzim\u00e1tica e m\u00e9todos para determina\u00e7\u00e3o de atividade antioxidante.<\/strong><\/p>\n

Descri\u00e7\u00e3o<\/h2>\n

Esta proposta tem como base o desenvolvimento de bioensaios, os quais poder\u00e3o ser utilizados em colabora\u00e7\u00e3o com todos os membros do INCTBioNat. Al\u00e9m disso, j\u00e1 dispomos de metodologias montadas e outras em desenvolvimento que abrangem ensaios antioxidantes, inibi\u00e7\u00e3o de enzimas envolvidas em processos inflamat\u00f3rios como mieloperoxidase, peroxidase de eosin\u00f3filos, cicloxigenase, lipoxigenase, etc.<\/p>\n

Principais Trabalhos Desenvolvidos<\/h2>\n
    \n
  1. BERTOZO, LUIZA DE CARVALHO; ZERAIK, MARIA LUIZA; XIMENES, VALDECIR FARIAS. Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase. ANALYTICAL BIOCHEMISTRY, v.532, p.29 – 37, 2017.<\/li>\n
  2. VENTURINI, DIEGO; DE SOUZA, AGUINALDO ROBINSON; CARACELLI, IGNEZ; MORGON, NELSON HENRIQUE; DA SILVA-FILHO, LUIZ CARLOS; XIMENES, VALDECIR FARIAS. Induction of axial chirality in divanillin by interaction with bovine serum albumin. PLoS One, v.12, p.e0178597, 2017.<\/li>\n
  3. WOLF, VANESSA GON\u00c7ALVES; BONACORSI, CIBELE; RADDI, MARIA STELLA GON\u00c7ALVES; DA FONSECA, LUIZ MARCOS; XIMENES, VALDECIR FARIAS. Octyl gallate, a food additive with potential beneficial properties to treat Helicobacter pylori infection. Food & Function, v.1, p.1 , 2017.<\/li>\n
  4. POTJE, SIMONE R.; TROIANO, J\u00c9SSICA A.; GRATON, MURILO E.; Ximenes, Valdecir F.; NAKAMUNE, ANA CLA\u00daDIA M.S.; ANTONIALI, CRISTINA. Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. Free Radical Biology & Medicine, v.106, p.148 – 157, 2017.<\/li>\n
  5. PARACATU, LUANA; ZERAIK, MARIA; DE CARVALHO BERTOZO, LUIZA; DE ANDRADE BARTOLOMEU, ALOISIO; DA SILVA FILHO, LUIZ; DA FONSECA, LUIZ; Ximenes, Valdecir. Synthesis, antioxidant and anti-inflammatory properties of an apocynin-derived dihydrocoumarin. Medicinal Chemistry. , v.12, p.1 – 1, 2016.<\/li>\n
  6. DE VASCONCELOS, D\u00c9BORA NALIATI; XIMENES, VALDECIR FARIAS. Albumin-Induced Circular Dichroism in Congo Red: Applications for Studies of Amyloid-like Fibril Aggregates and Binding Sites. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy (Print), v.150, p.321 – 330, 2015.<\/li>\n
  7. VENTURINI, DIEGO; PASTRELLO, BRUNA; ZERAIK, MARIA LUIZA; PAULI, IVANI; ANDRICOPULO, ADRIANO DEFINI; SILVA-FILHO, LUIZ CARLOS; BOLZANI, V. S.; MORGON, NELSON HENRIQUE; DA SOUZA, A. R.; XIMENES, VALDECIR FARIAS. Experimental, DFT and docking simulations of the binding of diapocynin to human serum albumin: induced circular dichroism. RSC Advances: an international journal to further the chemical sciences. , v.5, p.62220 – 62228, 2015.<\/li>\n<\/ol>\n

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