{"id":332,"date":"2017-11-22T11:33:35","date_gmt":"2017-11-22T13:33:35","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=332"},"modified":"2017-11-22T11:33:51","modified_gmt":"2017-11-22T13:33:51","slug":"angela-regina-araujo","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/pesquisadores\/angela-regina-araujo\/","title":{"rendered":"Angela Regina Araujo"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Professora Adjunto<\/h2>\n

Laborat\u00f3rio: <\/strong>NuBBE IQ\/UNESP<\/p>\n

Telefone:<\/strong>\u00a0+55 16 3301-9658<\/p>\n

E-mail:\u00a0<\/strong>araujoar@iq.unesp.br<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/lattes.cnpq.br\/0037579054083160<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n

Bioprospec\u00e7\u00e3o em fungos endof\u00edticos associados com esp\u00e9cies vegetais de biomas brasileiros<\/p>\n

Descri\u00e7\u00e3o<\/h2>\n

Isolamento, purifica\u00e7\u00e3o e cultivo de fungos endof\u00edticos associados a esp\u00e9cies vegetais utilizando t\u00e9cnicas adequadas, visando a obten\u00e7\u00e3o de metab\u00f3litos secund\u00e1rios com atividades biol\u00f3gicas como antioxidante, antif\u00fangica, antibacteriana, anticancer\u00edgena entre outras. T\u00e9cnicas de RMN 1D, 2 D, EM,\u00a0 IV, entre outras, s\u00e3o as ferramentas utilizadas para a determina\u00e7\u00e3o estruturas das subst\u00e2ncias isoladas.<\/p>\n

Desenvolve tamb\u00e9m varia\u00e7\u00e3o dos meios de cultivo utilizando aa t\u00e9cnica de OSMAC objetivando explorar a produ\u00e7\u00e3o metab\u00f3lica dos fungos endof\u00edticos via a ativa\u00e7\u00e3o de poss\u00edveis genes silenciosos.<\/p>\n

Principais Trabalhos Desenvolvidos<\/h2>\n
    \n
  1. Gubiani, Juliana R.\u00a0; Wijeratne, E.M. Kithsiri ; Shi, Taoda ;\u00a0Araujo, Angela R.\u00a0; Arnold, A. Elizabeth ; Chapman, Eli ; Gunatilaka, A.A. Leslie . An epigenetic modifier induces production of (10-S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma<\/em> sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla<\/em>. Bioorganic & Medicinal Chemistry<\/strong>, v. 25, p. 1860-1866, 2017.<\/li>\n
  2. Silva, Geraldo H.; Zeraik, Maria L. ; De Oliveira, Camila M. ; Teles, Helder L. ; Trevisan, Henrique C. ;\u00a0Pfenning, Ludwig H.; Nicolli, Camila P. ; Young, Maria C. M. ; Mascarenhas, Yvonne P. ; Abreu, Lucas M. ; Saraiva, Amanda C. ; Medeiros, Alexandra I. ; Bolzani, Vanderlan da S.;\u00a0Araujo, Angela R.\u00a0. Lactone Derivatives Produced by a sp., an Endophytic Fungus from. Journal of Natural <\/strong>Products<\/strong>, \u00a080, <\/em>\u00a0p 1674\u20131678, 2017.<\/li>\n
  3. Wijeratne, E. M. Kithsiri ; Gunaherath, G. M. Kamal B. ; Chapla, Vanessa M. ; Tillotson, Joseph ; De La Cruz, Fabian ; Kang, Minjing ; U’ren, Jana M. ;\u00a0Araujo, Angela R.\u00a0; Arnold, A. Elizabeth ; \u00a0 Chapman, Eli; Gunatilaka, A. A. Leslie . Oxaspirol B with p97 Inhibitory Activity and Other\u00a0 Oxaspirols from\u00a0Lecythophora\u00a0<\/em>sp.FL1375 and FL1031, Endolichenic Fungi \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Inhabiting\u00a0Parmotrema\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 tinctorum\u00a0<\/em>and\u00a0Cladonia evansii<\/em>. Journal of Natural Products<\/strong>, v. 79, p. 340-352, 2016.<\/li>\n
  4. Gubiani, J. R.; Habeck, T. R.; Chapla, V. M.; Silva, G.; Bolzani, V. S.; Araujo, A. R<\/strong>.<\/strong> One stain-many compounds (OSMAC) method for production of phenolic compounds using Camarops<\/em> sp., an endophytic fungus from Alibertia macrophylla<\/em> (Rubiaceae). Quimica Nova<\/strong>, v. 39, p. 1221-1224, 2016.<\/li>\n
  5. Gubiani, J. R. ; Araujo, A. R.; Bolzani, V. S.; Zeraik, M. Z.; Oliveira, C. M.; Ximenes, V. F.; Nogueira, C. R.; Fonseca, L. M.; Silva, D. H. S. Biologically Active Eremophilane-Type Sesquiterpenes from Camarops <\/em>sp., an Endophytic Fungus Isolated from Alibertia macrophylla<\/em>. Journal of Natural Products<\/strong>, 77, 668?672, 2014.<\/li>\n
  6. Chapla, V.; Zeraik, M.; Ximenes, V.; Zanardi, L.; Lopes, M.; Cavalheiro, A.; Silva, D.; Young, M.; Fonseca, L.; Bolzani, V.; Ara\u00fajo, A.. Bioactive Secondary Metabolites from Phomopsis<\/em> sp., an Endophytic Fungus from Senna spectabilis<\/em>. Molecules<\/strong>, v. 19, p. 6597-6608, 2014.<\/li>\n
  7. Camila M. Oliveira, Angela Regina Araujo, et. al.; Xylarenones C?E from an Endophytic Fungus Isolated from Alibertia macrophylla<\/em>. Journal of Natural Products<\/strong>, 74 (6), 1353\u20131357, 2011.<\/li>\n
  8. Camila M. Oliveira, Angela R. Araujo, et. al.; Dihydroisocoumarins produced by Xylaria<\/em> sp. and Penicillium<\/em> sp., endophytic fungi associated with Piper aduncum<\/em> and Alibertia macrophylla<\/em>. Phytochemistry Letters<\/strong>, 4, 93\u201396, 2011.<\/li>\n
  9. Geraldo H. Silva, Angela R. Araujo, et al.; Sesquiterpenes from Xylaria<\/em> sp., an endophytic fungus associated with Piper aduncum<\/em> (Piperaceae). Phytochemistry Letters<\/strong>, 3, 164-167, 2010.<\/li>\n
  10. Araujo, A. R.;\u00a0Young, Maria Claudia Marx;\u00a0Pfenning, Ludwig H.;\u00a0Eberlin, Marcos Nogueira\u00a0;\u00a0Haddad, Renato; Costs-Neto, Claudio Miguel; Castro-Gamboa, Ian. Cadinane Sesquiterpenoids of Phomopsis cassiae<\/em>, an endophytic fungus associated with Cassia spectabilis<\/em> (Leguminosae). Phytochemistry<\/strong>, v. 67, p. 1964-1969, 2006.<\/li>\n
  11. Sordi, R.; Castro-Gamboa, Ian ;\u00a0Pfenning, Ludwig H;\u00a0Young, Maria Claudia Marx\u00a0; Costa-Neto, Claudio Miguel ;\u00a0Araujo, A. R.\u00a0. New compounds from Periconia atropurpurea<\/em>, an endophytic fungus associated with Xylopia aromatica<\/em>. Phytochemistry<\/strong>, v. 67, p. 2686-2690, 2006<\/li>\n<\/ol>\n

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