{"id":392,"date":"2017-11-28T12:06:18","date_gmt":"2017-11-28T14:06:18","guid":{"rendered":"http:\/\/inct-bionat.iq.unesp.br\/?page_id=392"},"modified":"2017-11-28T12:06:18","modified_gmt":"2017-11-28T14:06:18","slug":"dulce-helena-siqueira-silva","status":"publish","type":"page","link":"http:\/\/inct-bionat.iq.unesp.br\/en\/participantes\/pesquisadores\/dulce-helena-siqueira-silva\/","title":{"rendered":"Dulce Helena Siqueira Silva"},"content":{"rendered":"

Sorry, this entry is only available in Portugu\u00eas do Brasil<\/a>. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.<\/p>

<\/p>\n

\"\"Prof. Associado<\/h2>\n

Laborat\u00f3rio: <\/strong>NuBBE<\/p>\n

Telefone:<\/strong>\u00a0+55 16\u00a03301-9680 \/ +55 16 99991-3551<\/p>\n

E-mail:<\/strong>\u00a0dhsilva@iq.unesp.br<\/a>\u00a0ou\u00a0dhsilva1@gmail.com<\/a><\/p>\n

Lattes:\u00a0<\/strong>http:\/\/buscatextual.cnpq.br\/buscatextual\/visualizacv.do?id=K4723030T4<\/a><\/p>\n

ORCID:<\/strong>\u00a0http:\/\/orcid.org\/0000-0002-1516-7765<\/a><\/p>\n

Linha de Pesquisa<\/h2>\n
    \n
  • Bioprospec\u00e7\u00e3o de produtos naturais de plantas e micro-organismos;<\/li>\n
  • Estudos qu\u00edmicos, ecol\u00f3gicos e biotecnol\u00f3gicos de micro-organismos do ambiente marinho.<\/li>\n<\/ul>\n

    Descri\u00e7\u00e3o<\/h2>\n

    Desenvolvemos pesquisa cient\u00edfica direcionada \u00e0 explora\u00e7\u00e3o sustent\u00e1vel da biodiversidade brasileira, visando a descoberta de novas mol\u00e9culas bioativas e potencialmente \u00fateis como nutrac\u00eauticos, agroc\u00eauticos ou para o desenvolvimento de f\u00e1rmacos.<\/p>\n

    Produtos naturais microbianos oriundos de fungos endof\u00edticos associados a algas marinhas t\u00eam evidenciado quimiodiversidade marcante e propriedades farmacol\u00f3gicas atrativas, que estimulam o uso de estrat\u00e9gias adicionais como o co-cultivo e de eliciadores epigen\u00e9ticos para indu\u00e7\u00e3o de vias biossint\u00e9ticas silenciosas e altera\u00e7\u00e3o de seu perfil metab\u00f3lico.<\/p>\n

    Ferramentas anal\u00edticas como RMN, EM e t\u00e9cnicas quir\u00f3pticas, estudos de desreplica\u00e7\u00e3o, al\u00e9m de bioensaios in vitro, enzim\u00e1ticos ou com uso de modelos animais alternativos realizados em colabora\u00e7\u00e3o integram a abordagem para estudos de virul\u00eancia, efic\u00e1cia e toxicidade voltadas \u00e0 bioprospec\u00e7\u00e3o de novos agentes antif\u00fangicos. Adicionalmente, modifica\u00e7\u00f5es estruturais e sistemas nanoestruturados para libera\u00e7\u00e3o controlada de subst\u00e2ncias bioativas tem sido utilizados para otimiza\u00e7\u00e3o da bioatividade.<\/p>\n

    Principais Trabalhos Desenvolvidos<\/h2>\n
      \n
    1. Bernardi, T ; Silva, JF ; Vicentin, J ; De Oliveira, HC ; Assato, PA ; Marcos, CM ; Paula Silva, ACA ; Da Silva, R A M, Regasini, LO;Silva, D. H. S.; da Silva Bolzani, V ; Fusco-Almeida, A M ; Mendes-Giannini, M J S . Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis<\/em> Medical Mycology<\/strong>, 2017.<\/li>\n
    2. Dametto, AC.; Agustoni, D ; Moreira, TF. ; Plaza, CV. ;Prieto, AM.; Silva, TG.A. ; Souza, FO. ; Boralle, N; Sorbo, JM ; Silva, D H.S.; Soares, C P. Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana<\/em> fruits and leaves. J Functional Foods<\/strong>, v. 36, p. 490-502, 2017.<\/li>\n
    3. Pedroso, M M; Foguel, M V ; Silva, D H S ; Sotomayor, M P T ; Yamanaka, H . Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer. Sensors And Actuators B-Chemical<\/strong>, v. 253, p. 180-186, 2017.<\/li>\n
    4. Preparing nano-structured lipid composition used for preparing medicament for treating paracoccidioidomycosis, involves stirring surfactant, oily phase and aqueous phase in transparent bottle using sonicator, where mixture is centrifuged. patente:\u00a0<\/strong>BR102015004661-A2. Depositante:\u00a0Univ Estadual Paulista. Inventor: Chorilli M. et al. 2017<\/li>\n
    5. Medina-Alarcon, K P; Singulani, J L. ; Voltan, A R; Sardi, J C O. ; Petronio, M S ; Santos, M B; Polaquini, C R. ; Regasini, L O.; Bolzani, V S.; Silva, D H. S.; Chorilli, M ; Mendes-Giannini, M J. S.; Fusco-Almeida, A M. Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for Paracoccidioides<\/em> brasiliensis<\/em> and Paracoccidioides lutzii<\/em> In Vitro. Frontiers in Microbiology<\/strong>, v. 8, p. 10.3389\/fmicb.2, 2017.<\/li>\n
    6. Zeraik, M L; Queiroz, E F; Marcourt, L ; Ciclet, O ; Castro-Gamboa, I ; Silva, D H S ; Cuendet, M ; Bolzani, V S ; Wolfender, J- L. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. J Functional Foods<\/strong>, v. 21, p. 396-405, 2016.<\/li>\n
    7. Arwa, P S ; Zeraik, M L ; Ximenes, V F ; Da Fonseca, L M; Bolzani, V S; Silva, D H S. Redox-active biflavonoids from Garcinia brasiliensis<\/em> as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage. J Ethnopharmacol<\/strong>, v. 174, p. 410, 2015.<\/li>\n
    8. Zeraik, M L; Petr\u00f4nio, M S. ; Coelho, D ; Regasini, L O ; Silva, D. H. S. ; Da Fonseca, L M ; Machado, S A S; Bolzani, V S.; Ximenes, V F. Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification. PLOS One<\/strong>, v. 9, p. e110277, 2014.<\/li>\n
    9. Funari, C S, Eugster, P. J., Martel, S., Carrupt, P.-A., Wolfender, J. L., Silva, D H S. High resolution ultra-high pressure liquid chromatography-time-of-flight mass spectrometry dereplication strategy for the metabolite profiling of Brazilian Lippia<\/em> J. Chromatography A<\/strong>, v. 1259, p. 167-178, 2012.<\/li>\n
    10. Funari, CS;\u00a0Gullo, FP; Napolitano, A ;\u00a0Carneiro, RL, Mendes-Giannini, MJS; Fusco-Almeida, AM; Piacente, S ; Pizza, C ;\u00a0Silva, DHS. Chemical and antifungal investigations of six Lippia<\/em> species (Verbenaceae) from Brazil. Food Chemistry<\/strong>, v. 135, p. 2086-2094, 2012.<\/li>\n
    11. Nazare, A. C.;Petr\u00f4nio, M. S.; Paracatu, L. C;Zeraik, M.L.; Regasini, LO; SILVA, D. H. S.; Ximenes, V F. Protocatechuic acid alkyl esters: hydrophobicity as a determinant factor for inhibition of NADPH oxidase. Curr Med Chemistry<\/strong>, v. 19, p. 1, 2012.<\/li>\n
    12. Funari, C S; Passalacqua, TG ;\u00a0Rinaldo, D; Napolitano, A ; Festa, M ; Capasso, A ; Piacente, S; Pizza, C ; Young, MCM; Durigan, G; Silva, D H S. Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry<\/strong>, v.72, p. 2052-2061, 2011.<\/li>\n
    13. Ximenes, V F.; Lopes, M G. ;\u00a0Petronio, MS, Regasini, LO, Silva, D H.; da Fonseca, L M. . Inhibitory Effect of Gallic Acid and Its Esters on 2,2?-Azobis(2-amidinopropane)hydrochloride (AAPH)-Induced Hemolysis and Depletion of Intracellular Glutathione in Erythrocytes. J Agric Food Chemistry<\/strong>, v. 58, p. 5355-5362, 2010.<\/li>\n
    14. Morais, M Luqman, S; Kondratyuk, T; Petronio, M, Regasini, L, Soares, C; Pezzuto, J ; Silva, D H S. Suppression of TNF-a induced NFkB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. Nat Prod Res<\/strong>, v. 24, p. 1758-1765, 2010.<\/li>\n
    15. Balbani, Aracy PS; Silva, DHS; Montovani, J C . Patents of drugs extracted from Brazilian medicinal plants. Expert Opinion on Therapeutic Patents, v. 19, p. 461-473, 2009.<\/li>\n<\/ol>\n

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